trans-Capsaicin is a highly refined product with few impurities and has been the preferred active for dermal patches and other medicinal uses. Many have reported that trans-capsaicin is more effective than the 95% natural product or nonivamide.
Medicinal and Cosmetic
Trans-capsaicin is used in dermal patches, topical ointments, and creams to relieve minor aches and pains of muscles and joints. Trans-capsaicin is also available in large adhesive bandages that can be applied to the back. It has been reported that a single, hour-long application of a high-concentration trans-capsaicin skin patch provided an average of 19 weeks of sustained reduction in the pain of neuralgia. In fact, one-eighth of the patients in a year-long multi-center, double-blind, randomized clinical trial of a dermal patch experienced such durable pain relief that they never required re-treatment. The others obtained a year of substantial pain relief with four 1-hour dermal applications of the trans-capsaicin patch.
Concentrations are typically between 0.025% and 0.075%. Research suggests that capsaicin is able to kill prostate cancer cells. The studies showed tumors treated with capsaicin were about one-fifth the size of the untreated tumors. One study suggests capsaicin may be effective against lung cancer cells and researchers in Canada are testing capsaicin as a cure for diabetes.
Food and Beverage
Recently, capsaicin has been added to beverages to ‘spice’ them up. Because of the high purity, trans-Capsicin is well-suited for human consumption.
|Formula:||C18 H27 NO3|
|Appearance||White to Off White Powder|
|Odor||Very highly pungent and easily penetrating odor|
|Assay by HPLC||98.0% – 102.0%|
|Isometric Purity by HPLC (trans)||≥ 94.0% (area) trans-Capsaicin|
|Isometric Purity by HPLC (cis)||≤ 6.0% (area) cis-Capsaicin|
|Melting Point||64°C – 67°C|
|Loss on Drying||≤1.0%|
|Residue on Ignition||≤0.1%|
|Water, %, by KF||≤1.0%|
Solubility: Capsaicin in its pure state is poorly soluble in water but soluble in oil