Aversion Technologies, Inc.

Protecting People, Pets and Plants



Cis-capsaicin is used for the treatment of primary or recurrent herpes, as a topical analgesic used to treat osteoarthritis of the knee and other neuropathic pain. It is a tool used in neurobiological research.


Medicinal and Cosmetic
Cis-capsaicin is used in dermal patches, topical ointments, and creams to relieve minor aches and pains of muscles and joints. It has been reported that a single, hour-long application of a high-concentration capsaicin skin patch provided an average of 19 weeks of sustained reduction in the pain of neuralgia. In fact, one-eighth of the patients in a year-long multicenter, double-blind, randomized clinical trial of a dermal patch experienced such durable pain relief that they never required re-treatment. The others obtained a year of substantial pain relief with four 1-hour dermal applications of the capsaicin patch.

Concentrations are typically between 0.025% and 0.075%. Research suggests that capsaicin is able to kill prostate cancer cells. The studies showed tumors treated with capsaicin were about one-fifth the size of the untreated tumors. One study suggests capsaicin may be effective against lung cancer cells and researchers in Canada are testing capsaicin as a cure for diabetes.

Food and Beverage
Recently, capsaicin has been added to beverages to 'spice' them up.


Chemical Names 
A) Trans-8-methyl-n-vanillyl-6-nonenamid
B) N-[(4-Hydroxy-3-methoxyphenyl)-8-methyl-6-nonenamide


Product Name:                                  cis-Capsaicin
CAS No:                                           404-86-4
Specification:                                    USP 30
Formula:                                          C18 H27 NO3

Appearance   White to Off White Powder
Odor                                                 Very highly pungent and easily penetrating odor
Assay by HPLC 99.0% - 102.0%
Isometric Purity by HPLC (trans) ≥ 99.0% (area) trans-Capsaicin
Melting Point 64°C – 67°C
Loss on Drying  ≤0.1%
Residue on Ignition ≤0.1%
Water, %, by KF ≤0.2%

Solubility: Capsaicin in its pure state is poorly soluble in water but soluble in oil, chloroform, ethyl acetate